appendix 1 and 2

Appendix 2

Three out of our five patients (cases 1-3) showed elevated ammonia serum levels. Very high ammonia levels have previously been described in patients with VE, even with normal liver function tests [21], and it has been hypothesised that the manifestations of VE are directly related to hyperammonaemia. VPA can increase the transport of glutamine across the mitochondrial membrane in the kidney, th...

Appendix B.2

Appendix 2.qxd

on the adult skull. The skull of the infant, and more so in the neonate by necessity, is immensely malleable, with the pliability of a milk carton. As a mainly cartilaginous structure at birth, the infant skull is ultraresponsive to direct molding pressures. The evolution of the neurocranium, through different growth centers, as well as the main sutural features of the skull and face are shown ...

Appendix S 1

Appendix 1 Theoretical Aspects

pathways according to the method shown in Appendix 1. The results for rat heart are summarized in Scheme 1. In the absence of nucleoside triphosphates, the pathway involving the dephosphorylation of AMP is 16 times more active than the otie involving deamination of AMP. In the presence of ATP, the pathway involving deamination of AMP is 3.1 times more active than the one involving its dephospho...

APPENDIX Reviewer 1